Introduction
Nasal polyps are soft, non-cancerous growths associated with chronic inflammation of the nose and sinuses. They may cause persistent nasal blockage, loss of smell, facial pressure, postnasal drainage, and recurrent sinus infections.
Dr. Tamer Fawzy provides comprehensive nasal polyps treatment in Dubai, including medical therapy, minimally invasive sinus surgery, and biologic treatment for selected patients with severe or recurrent disease.
Biologic therapy targets specific inflammatory pathways involved in nasal polyp growth. It may be considered when symptoms remain uncontrolled despite appropriate medical treatment, when polyps return after surgery, or when repeated courses of oral corticosteroids are required.
What Are Biologics?
Biologics are targeted medicines designed to block specific immune pathways involved in chronic inflammation. Unlike treatments that provide temporary symptom relief, biologic therapy focuses on the inflammatory process contributing to the growth and recurrence of nasal polyps.
Treatment is usually given by injection at scheduled intervals. The medication selected, dosing schedule, and duration of treatment depend on the patient’s diagnosis, inflammatory profile, associated medical conditions, and response to therapy.
Benefits may include:
- Reduction of nasal polyp size
- Improved nasal breathing
- Restoration of smell
- Fewer sinus infections
- Reduced need for oral steroids
- Lower likelihood of repeat sinus surgery
Biologic Medicines Used for Nasal Polyps
- Dupilumab (Dupixent): targets the IL-4 and IL-13 pathways.
- Mepolizumab (Nucala): targets IL-5 and eosinophilic inflammation.
- Omalizumab (Xolair): targets immunoglobulin E, known as IgE.
- Tezepelumab (Tezspire): targets thymic stromal lymphopoietin, known as TSLP.
Biologic Therapy vs Sinus Surgery
Biologic therapy and endoscopic sinus surgery have different roles in the management of nasal polyps.
Sinus surgery removes obstructing polyps and opens the affected sinuses to improve ventilation, drainage, and access for topical treatment. Biologic therapy does not physically remove polyps; it targets inflammatory pathways that contribute to their growth and recurrence.
Some patients may benefit from surgery, others may be suitable for biologic therapy, and selected patients may require both as part of a long-term treatment plan. Dr. Tamer Fawzy recommends the most appropriate option after reviewing symptom severity, previous treatment, nasal endoscopy findings, imaging, associated asthma, and the effect of the condition on quality of life
Who Is a Candidate for Biologic Therapy?
Biologic therapy is generally considered for selected patients with severe or uncontrolled chronic rhinosinusitis with nasal polyps. It is not usually the first treatment offered for mild nasal polyps.
Before recommending biologic therapy, Dr. Tamer Fawzy may review previous medical and surgical treatments, perform nasal endoscopy, assess the sense of smell and symptom severity, and request imaging or laboratory investigations when appropriate.
Biologic therapy may be considered when:
- Nasal polyps remain uncontrolled despite appropriate medical treatment.
- Polyps recur following previous nasal polyp surgery.
- Significant nasal obstruction or loss of smell continues.
- Repeated courses of oral corticosteroids are required or are unsuitable.
- Nasal polyps have a significant effect on daily activities and quality of life.
- Asthma or evidence of Type 2 inflammation is also present
Your Nasal Polyps Treatment Pathway
- Step 1 – Comprehensive Assessment
- Step 2 – Nasal Examination
- Step 3 – Initial Medical Treatment
- Step 4 – Surgery or Biologic Therapy
- Step 5 – Monitoring Treatment Response
Why Choose Dr. Tamer Fawzy for Nasal Polyps Treatment in Dubai?
Dr. Tamer Fawzy provides individualized nasal polyps treatment in Dubai using a combination of detailed diagnostic assessment, evidence-based medical therapy, minimally invasive sinus surgery, and biologic treatment when clinically appropriate.
With more than 20 years of international ENT experience and advanced training in endoscopic sinus surgery, he evaluates the underlying cause and severity of the condition before recommending treatment. The aim is to improve breathing and smell, reduce the burden of recurring symptoms, and support long-term control of sinus inflammation.
Learn more about Dr. Tamer Fawzy’s experience and qualifications
